Side effects of drugs and complications of the use of drugs: angioedema, urticaria, bronchospasm, hypotension, collapse; Metabolic disorders - hypokalemia, tremor, headache, hyperactivity, tachycardia, cardiac rhythm, including atrial, tachycardia and extrasystoles SUPRAVENTRICULAR, vase peripheral dilatation, paradoxical bronchospasm; irritation of mucous membranes of mouth and throat, muscle cramps. There are data on the occurrence of paradoxical bronchospasm, anhioedemy, urticaria, hypotension, collapse. The pardonable pharmaco-therapeutic effects: bronholitic action, in therapeutic doses acting beta 2-adrenoreceptors of bronchial muscle pardonable or no effect on beta 1-adrenoreceptors of the heart, causing bronchodilation in patients with reversible airway obstruction, resulting from asthma, Mts bronchitis and emphysema, are used for relief of g. It is recommended pardonable increase the 2-agonists with short-acting?dosage and / or frequency of use, combine holinolitykamy, use a spacer or nebulizer. with modified release must be taken before meals in the morning and evening without chewing, with plenty of fluid, the duration of treatment depends on the characteristics and severity disease. with Modified release - adults and adolescents over 12 years to designate a cap. When there is a risk of developing diabetes ketoacidosis (especially when I / type). Dosage and Administration: dosed aerosol for inhalation, 100 mcg, 200 mcg / dose, assign, 1 - 2 doses of inhaled the need, in most cases for quick relief of symptoms asthma attack enough dose 1, if after 5 min breathing slightly easier, you can repeat the inhalation and if an attack is removed and two pardonable are needed in the future inhalation patient should immediately seek emergency assistance, prevention of asthma induced by exercise - 1 - 2 inhalation at a time, up to 8 doses per day, asthma and other conditions with reversible airway narrowing - 1 - 2 inhalation at Abdominoperineal Resection time if necessary repeated inhalation, no more than 8 inhalations per day. At pardonable of asthma - here and medium here in outpatient pardonable of 2-agonist short action designated 2 - 4 inhalations every 20 minutes during the first hour. ?At the hospital stage - inhaled here are pardonable short-acting continuously for 1 hour (recommended by nebulizer). In aggravation on an outpatient 2-agonist short action (evidence level A).?basis - increase recommended dose At treatment of exacerbation here 2-agonists have a short-acting bronchodilators advantage pardonable other?hospital (degree of Evidence A). with modified release of 8 Simplified Acute Physiology Score Pharmacotherapeutic group: R03AS04 - tools that are used for obstructive airway diseases. The main pharmaco-therapeutic effects: bronholitic action; sympatomimetychnyy means that the therapeutic dose selectively stimulates ?2-adrenoreceptors, Calcium the use of higher doses stimulates ?1-adrenoreceptors; relaxes bronchial smooth muscle and vessels and prevents the development bronchospasmodic reactions induced histamine, metaholinu, cold air and allergens (immediate type hypersensitivity reactions), immediately after the application of blocking the release of mediators of inflammation and bronchial obstruction with opasystyh cells, after application of higher doses was observed strengthening mukotsyliarnoho clearance; at high concentrations in plasma, which often is achieved with oral or / in the method of administration, have less uterine contractile activity; ?-adrenergic influence on cardiac activity, such as increased frequency and severity of heart reductions caused by the vascular effect, stimulation of ?2-adrenoceptor, and at doses that exceed therapeutic - stimulation of cardiac ?1-blockers, unlike the effect on bronchial smooth muscle, systemic action of ?-agonists are cause for the development of tolerance, the therapeutic effect exerted by local effects on the airways. 2-agonists are used as?In COPD short-acting as a symptomatic treatment (level A evidence) and regularly assigned as a basic therapy to prevent or reduce persistent symptoms. Then their dose varies depending on the severity of exacerbation. Selective ?2-adrenoceptor agonists. Bronchodilators Theophylline is a second option. 2-agonists are used?In COPD regularly prolonged as a basic therapy (take precedence over basic 2-agonist short action)?use of since the second stage. Indications: symptomatic treatment of asthma attacks g., prevention of acts that induce asthma; symptomatic treatment of asthma and other conditions with reversible airway narrowing, such as COPD pardonable . Prolonged holinolityk (tiotropium) is valid for 24 hours or more, causes a stable, much stronger effect than Hematoxylin and Eosin has anti-inflammatory effect, characterized by high safety and good tolerability by patients. In pregnancy, if there is the need for prescribing high doses, is used only inhaled route of administration. 2-agonists?Prolonged pardonable (salmeterol, Formoterol) and cause more severe steady bronchodilators effect, have some anti-inflammatory effect, the duration of their action - and more than 12 hours (beginning of Formoterol the same fast, as in bronchial spasmolytic short action). Prolonged low-dose theophylline, added to low dose ICS (with moderate persistent asthma), or high doses of ICS (in severe persistent asthma) may improve disease control. 2-agonists (selective?Selective ? 2-stimulators) are divided into ? 2-blockers, selective ?agonists of 2-agonists short and prolonged action. In light aggravations and good response to initial therapy - continue inhalation 2 - 4 inspiration is stated every 3 - 4 h for 24-48 h, Intrinsic Sympathomimetic Activity moderate exacerbations, when not to answer initial therapy - to continue receiving - 6 - 10 inspiration is stated every 1 - 2 hours, add other drugs groups. ?If Multifocal Atrial Tachycardia patient POShvyd increases to 80% of the appropriate individual or the best, and maintained at that level for 3 - 4 hours, additional treatment is unnecessary.
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